Name: Recombinant Human SMARCA4
Price: Inquiry

- Overview
  - SMARCA4 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 211 amino acids (362-549aa) andhaving a molecular mass of 25kDa. SMARCA4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. SMARCA4 belongs to the SWI/SNF family of proteins and is similar to thebrahma protein of Drosophila. Proteins in this family have helicase and ATPase activities and are consideredto regulate transcription ofcertain genes by altering the chromatin structure around those genes. SMARCA4is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is essential for transcriptional activation of genes normally repressed by chromatin. Inaddition, SMARCA4 is able to bind BRCA1, as well as regulating the expressionof thetumorigenic protein CD44. Moreover, mutations in SMARCA4 cause rhabdoid tumorpredisposition syndrome type 2.
    
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- Properties
  - Protein Name
    
    SWI/SNF Related, Matrix Associated, Actin DependentRegulator Of Chromatin, Subfamily A, Member 4, Mitotic Growth And TranscriptionActivator, ATP-Dependent Helicase SMARCA4, BRG1, Global Transcription ActivatorHomologous Sequence Sucrose Nonferme
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 80.0% as determined by SDS-PAGE.
    
    Formulation
    
    SMARCA4 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human SMARCA4

Recombinant Human SMARCA4

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