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Overview
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SNAI1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-264 a.a) and having a molecular mass of 31.5kDa. SNAI1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Snailhomolog 1 (SNAI1) is involved in induction of the epithelial to mesenchymaltransition (EMT), formation and maintenance of embryonic mesoderm, growtharrest, survival and cell migration. SNAI1 binds to 3 E-boxes of the E-cadheringene promoterand represses its transcription. The nuclear protein encoded by SNAI1 isstructurally identical to the Drosophila snail protein, and is considered aswell to be vital for mesoderm formation in the developing embryo. At least twovariants of a similar processed pseudogene have been found on chromosome 2. Among the diseases associated with SNAI1 are waardenburgsyndrome type iid, and inappropriate adh syndrome.
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Overview