Name: Recombinant Human Serpin Peptidase Inhibitor, Clade C Member 1
Price: Inquiry

- Overview
  - SERPINC1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 455 amino acids (33-464 a.a) and having a molecular mass of 51.4kDa. SERPINC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Serpin Peptidase Inhibitor, Clade C Member 1 (SERPINC1), which is a part of the serpin superfamily, is a plasma protease inhibitor. SERPINC1 inhibits thrombin and other activated serine proteases of the coagulation system, and regulates the blood coagulation cascade. SERPINC1 also inhibits Thrombin and Factors IXa, Xa and XIa. The inhibitory activity of SERPINC1 is significantly enhanced in the presence of heparin. Deficiencies in SERPINC1 can cause ATIII deficiency, an autosomal dominant disease which might lead to a hereditary thrombophilia.
    
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- Properties
  - Protein Name
    
    AT3, AT3D, ATIII, THPH7, Antithrombin-III, Serpin C1, SERPINC1.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 85.0% as determined by SDS-PAGE.
    
    Formulation
    
    SERPINC1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Serpin Peptidase Inhibitor, Clade C Member 1

Recombinant Human Serpin Peptidase Inhibitor, Clade C Member 1

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