Recombinant Human ROR1 Protein with C-terminal 6×His tag

Recombinant Human ROR1 Protein with C-terminal 6×His tag

Catalog Number:
P001417568ABE
Mfr. No.:
Abe32-17143
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      • Overview
        • The protein has a predicted molecular mass of 42.8 kDa after removal of the signal peptide. The apparent molecular mass of ROR1-His is approximately 55-70 kDa due to glycosylation. This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

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      • Properties
        • Protein Name
          ROR1, NTRKR1
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Purification
          The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
          Formulation
          Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
          Storage
          Store at -80°C for 12 months (Avoid repeated freezing and thawing)

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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