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Overview
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RBM3 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (1-157 a.a) and having a molecular mass of 19kDa. RBM3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. RBM3belongs to the glycine-rich RNA-binding protein family and encodes a proteinwith one RNA recognition motif (RRM) domain. Bycold shock and low oxygen tension the expression of this gene is induced. Onchromosome 1 a pseudogene exists. Alternate transcriptional splice variants,encoding different isoforms, have beencharacterized. Diseases associated with RBM3include vaccinia, andcryptorchidism. GO annotations linked to this geneinclude RNA binding and ribosomal large subunit binding. Animportant paralog of this gene is RBMY1J.
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Overview