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Recombinant Human RET (N-GST tag)

Recombinant Human RET (N-GST tag)

Catalog Number:
E001278536APP
Mfr. No.:
Z500337
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • RET gene codes for a transmembrane tyrosine kinase which is a subunit of a multimeric complex that acts as a receptor for four structurally related molecules: GDNF, neurturin, artemin and persephin. Germline mutations of RET cause a dominantly inherited dysgenesis of the enteric nervous system known as Hirschsprung's disease. RET is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). Several single nucleotide polymorphisms of the RET gene have been described. Multiple endocrine neoplasia type 2A (MEN 2A) have been reported to be associated with two mutations of the protooncogene RET.

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      • Properties
        • Name
          PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, RET-ELE1
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          74.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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