Name: Recombinant Human Regulator of G-Protein Signaling 1
Price: Inquiry

- Overview
  - RGS1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (1-209 a.a) and having a molecular mass of 26kDa. RGS1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. RGS1 belongs to the regulator of G-protein signaling family. The RGS1 protein is situated on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif termed the RGS domain. RGS1 diminish s the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and performing as a GTPase activating protein (GAP), boosting the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, creating inactive G-protein heterotrimers, thus terminating the signal.
    
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- Properties
  - Protein Name
    
    Regulator of G-protein signaling 1, RGS1, B-cell activation protein BL34, Early response protein 1R20, 1R20, BL34, IER1, IR20.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 90% as determined by SDS-PAGE.
    
    Formulation
    
    RGS1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Regulator of G-Protein Signaling 1

Recombinant Human Regulator of G-Protein Signaling 1

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