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Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-2/HER2 (C-Fc)

Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-2/HER2 (C-Fc)

Catalog Number:
P001411525ABE
Mfr. No.:
Abe32-9714
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      • Overview

        • Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity. It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5-TCAAATTC-3 sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

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      • Properties
        • Protein Name
          Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Tyrosine kinase-type cell surface receptor HER2, ERBB2, MLN19, NGL, TKR1
          Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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