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Recombinant Human V-Set and Ig Domain-Containing Protein 4/VSIG4/CRIg (C-Fc)

Recombinant Human V-Set and Ig Domain-Containing Protein 4/VSIG4/CRIg (C-Fc)

Catalog Number:
P001411526ABE
Mfr. No.:
Abe32-9715
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      • Overview

        • V-set and immunoglobulin domain-containing protein 4(VSIG4) is a transmembrane protein contains a signal peptide, a V-type Ig-like domain, a C2-type Ig-like domain, several potential O-glycosylation sites, and an intracellular domain with 2 potential phosphorylation sites and is structurally related to the B7 family of immune regulatory proteins. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. The main function is strong negative regulator of T-cell proliferation and IL2 production and it is also potent inhibitor of the alternative complement pathway convertases. It abundantly expressed in several fetal tissues such as adult tissues, highest expression in lung and placenta and it also expressed in resting macrophages.

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      • Properties
        • Protein Name
          V-set and immunoglobulin domain-containing protein 4, VSIG4, Protein Z39Ig, Z39IG, CRIg
          Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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