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Overview
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PSG5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 324 amino acids (35-335) and having a molecular mass of 36.4kDa. PSG5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. PSG5 belongs to the PSG family, which are a highly connected group of secreted glycoproteins, vastly expressed in fetal placental syncytiotrophoblast cells. PSGs are can be found in serum from the first 2-3 weeks of pregnancy and at higher levels as the pregnancy progresses, up to e point where they are the highest fetal protein found in maternal blood at term. PSG5's role is inducing secretion of TH2-type cytokines from monocytes and modulating the maternal immune system throughout the pregnancy, thus defending the semi-allotypic fetus from rejection.
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- Properties
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Overview