Name: Recombinant human PMEL Protein with C-terminal Human Fc tag
Price: Inquiry

- Overview
  - The protein has a predicted molecular mass of 46.2 kDa after removal of the signal peptide. The apparent molecular mass of PMEL-hFc is approximately 130-250 kDa due to glycosylation. This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
    
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- Properties
  - Protein Name
    
    D12S53E, gp100, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV
    
    Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
    
    Formulation
    
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
    
    Storage
    
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human PMEL Protein, hFc Tag on SDS-PAGE under reducing condition.

Recombinant human PMEL Protein with C-terminal Human Fc tag

Recombinant human PMEL Protein with C-terminal Human Fc tag

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