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Recombinant Human Phosphatidylinositol 4-Kinase beta/PI4KB (C-6His)

Recombinant Human Phosphatidylinositol 4-Kinase beta/PI4KB (C-6His)

Catalog Number:
P001411239ABE
Mfr. No.:
Abe32-7700
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      • Overview

        • MW : 90.8kD. Recombinant Human PI4KB is produced by our Mammalian expression system and the target gene encoding Met1-Met801 is expressed with a 6His tag at the C-terminus. Phosphatidylinositol 4-Kinase beta (PI4KB) belongs to the PI3/PI4-kinase family and Type III PI4K subfamily. PI4KB contains one PI3K/PI4K domain and one PIK helical domain. It is highly expressed in heart, skeletal muscle, pancreas, testis and ovary; it is lowly expressed in liver tissue. PI4KB kinase activity can be inhibited by wortmannin, and increased by interacting with NCS1/FREQ. PI4KB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). In addition, PI4KB may regulate Golgi disintegration/reorganization during mitosis.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Supplied as a 0.2 µm filtered solution of 25mM Tris. HCl, pH7.3, 100mM glycine, 10%glycerol.
          Storage
          Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          Q9UBF8
          Gene ID
          5298

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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