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Recombinant Human PDK1 (N-His tag)

Recombinant Human PDK1 (N-His tag)

Catalog Number:
E001278487APP
Mfr. No.:
Z500283
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
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      • Overview

        • PDK1 (3-phosphoinositide-dependent protein kinase) is activated by the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2. PDK1 then activates protein kinase B (PKB) which, in turn, inactivates glycogen synthase kinase-3 (GSK3). The phosphorylation of other proteins by PKB and GSK3 is likely to mediate many of the intracellular actions of insulin. Thus, PDK1 plays a key role in mediating many of the actions of the second messenger(s) PtdIns(3,4, 5)P3 and/or PtdIns(3,4)P2. The human PDK1 is a 556-residue monomeric enzyme comprising of a catalytic domain that is most similar to the PKA, PKB and PKC subfamily of protein kinases.

          Please contact us at for specific academic pricing.

      • Properties
        • Name
          PRO0461; PDPK1; MGC20087; MGC35290; PkB-like; PkB-like 1
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          67.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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