Name: Recombinant Human PAPS Synthase 1/PAPSS1 (C-6His)
Price: Inquiry

- Overview
  - MW : 71.9kD. Recombinant Human PAPS synthase 1 is produced by our Mammalian expression system and the target gene encoding Met1-Ala624 is expressed with a 6His tag at the C-terminus. PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
    
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- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Supplied as a 0.2 µm filtered solution of 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 20% glycerol.
    
    Storage
    
    Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    O43252
    
    Gene ID
    
    9061
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human PAPS Synthase 1/PAPSS1 (C-6His)

Recombinant Human PAPS Synthase 1/PAPSS1 (C-6His)

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