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Recombinant Human nudE Nuclear Distribution Gene E Homolog 1

Recombinant Human nudE Nuclear Distribution Gene E Homolog 1

Catalog Number:
P001413550ABE
Mfr. No.:
Abe32-4302
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  • Size:
    20 µg
    Quantity:
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      • Overview

        • NDE1 produced in E. Coli is a single, non-glycosylated polypeptide chain containing 355 amino acids (1-335 a.a.) and having a molecular mass of 39.9kDa (Molecular weight on SDS-PAGE will appear higher). NDE1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. NDE1 is a cytoplasmic protein which is a member of the nudE protein family. Phosphorylated during mitosis, NDE1 is critical for the formation and function of the mitotic spindle in M phase and functions to regulate the Dynein-mediated transport of kinetochore proteins, as well as centrosome duplication during interphase. NDE1 is believed to interact with NDEL1, LIS1 and Dynein IC1/2, cytosolic in a signaling pathway which regulates the formation of neurons and is fundamental to the development of the cerebral cortex.

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      • Properties
        • Protein Name
          Nuclear distribution protein nudE homolog 1, NudE, NDE1, NUDE, LIS4, NUDE1, HOM-TES-87.
          Source
          E. coli
          Type
          Recombinant Proteins
          Purification
          Greater than 85.0% as determined by SDS-PAGE.
          Formulation
          The NDE1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 5mM DTT and 0.2M NaCl.
          Storage
          NDE1 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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