Name: Recombinant Human Non-SMC Element 1
Price: Inquiry

- Overview
  - NSMCE1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 289 amino acids (1-266) and having a molecular mass of 33.0kDa. NSMCE1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. NSMCE1 is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). NSMCE1 has in vitro ubiquitin ligase activity in presence of NDNL2.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    Non-SMC Element 1 Homolog (S. Cerevisiae), NSE1, Non-Structural Maintenance of Chromosomes Element 1 Homolog, Non-SMC Element 1 Homolog, EC 6.3.2.-.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 95% as determined by SDS-PAGE.
    
    Formulation
    
    The NSMCE1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Non-SMC Element 1

Recombinant Human Non-SMC Element 1

We Also Recommend

Recombinant Human Neurotensin

Recombinant Human NHP2 Non-Histone Chromosome Protein 2-Like

Recombinant Human Nuclear Import 7 Homolog