Name: Recombinant Human NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)
Price: Inquiry

- Overview
  - MW : 16.9kD. Recombinant Human NKG2-D type II Integral Membrane Protein is produced by our expression system and the target gene encoding Phe78-Val216 is expressed with a 6His tag at the N-terminus. NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
    
    Storage
    
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    P26718
    
    Gene ID
    
    100528032
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)

Recombinant Human NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)

More Information

We Also Recommend

Recombinant Mouse CD27/TNFRSF7 (C-Fc-6His)

Recombinant Mouse Fas/TNFRSF6/CD95 (C-6His)

Recombinant Mouse Fc Receptor-like Protein 1/FCRL1/FcRH1 (C-6His)