Recombinant Human Methylmalonyl-CoA Epimerase/MCEE (C-6His)

Recombinant Human Methylmalonyl-CoA Epimerase/MCEE (C-6His)

Catalog Number:
P001412291ABE
Mfr. No.:
Abe32-8462
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      • Overview
        • MW : 16kD. Recombinant Human Methylmalonyl-CoA epimerase is produced by our Mammalian expression system and the target gene encoding Gln37-Ala176 is expressed with a 6His tag at the C-terminus. Methylmalonyl-CoA epimerase, mitochondrial(MCEE)is an enzyme which belongs to the glyoxalase I family. It converts (S)-methylmalonyl-CoA to the (R) form, catalyses the following chemical reaction: (R)-methylmalonyl-CoA (S)-methylmalonyl-CoA. It plays an important role in the catabolism of fatty acids with odd-length carbon chains. This protein deficiency is an autosomal recessive inborn error of AA metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria can appear in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM DTT, 10% Glycerol, pH7.5.
          Storage
          Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          Gene ID
          84693

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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