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Recombinant Human KSR1 (431-end) (N-GST tag)

Recombinant Human KSR1 (431-end) (N-GST tag)

Catalog Number:
E001278401APP
Mfr. No.:
Z500192
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • KSR1 or Kinase Suppressor of Ras 1 interacts with various kinases of the Raf/MEK/extracellular signal-regulated kinase pathway to enhance its activation. KSR1 is regulated in response to a specific mode of dimerization of its kinase domain, which is termed the side-to-side dimer, whereas KSR1 also participates in forming side-to-side heterodimers with RAF and this can trigger RAF activation. KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways. KSR1 functions as a scaffold that enhances iNOS activity and is crucial for the pulmonary response to P. aeruginosa infection.

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      • Properties
        • Name
          KSR; RSU2
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          66.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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