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Recombinant Human ITK (N-GST tag)

Recombinant Human ITK (N-GST tag)

Catalog Number:
E001278377APP
Mfr. No.:
Z500183
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor. ITK requires prior activation of LCK, ZAP70 and PI3-kinase for efficient activation and shares major substrates with both LCK and ZAP70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization.

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      • Properties
        • Name
          EMT; LYK; PSCTK2; MGC126257; MGC126258
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          108.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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