Name: Recombinant Human Importin Subunit Beta-1/KPNB1(N-6His)
Price: Inquiry

- Overview
  - MW : 98.6kD. Recombinant Human Importin Subunit Beta-1 is produced by our E.coli expression system and the target gene encoding Met1-Ala876 is expressed with a 6His tag at the N-terminus. Importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Its functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits. Each of these subunits is part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Supplied as a 0.2 µm filtered solution of 20mM Tris, 1mM DTT, 30% glycerol, 0.1M Nacl, pH8.0.
    
    Storage
    
    Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    Q14974
    
    Gene ID
    
    3837
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Importin Subunit Beta-1/KPNB1(N-6His)

Recombinant Human Importin Subunit Beta-1/KPNB1(N-6His)

More Information

We Also Recommend

Recombinant Human Annexin A2/ANXA2

Recombinant Human Annexin A7/ANXA7

Recombinant Human Stratifin/SFN