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Recombinant Human IL-12 Receptor Subunit beta1/IL-12RB1/CD212 (C-Fc)

Recombinant Human IL-12 Receptor Subunit beta1/IL-12RB1/CD212 (C-Fc)

Catalog Number:
P001412406ABE
Mfr. No.:
Abe32-8617
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      • Overview

        • MW : 84.2kD. Recombinant Human IL-12 receptor beta 1 is produced by our Mammalian expression system and the target gene encoding Cys24-Glu540 is expressed with a Fc tag at the C-terminus. Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
          Storage
          Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          P42701
          Gene ID
          3594

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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