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Overview
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SAR1B Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-198 a.a) and having a molecular mass of 24.8kDa. SAR1B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. SAR1B is a small GTPase that functions as a homodimer. GTP-Binding Protein SAR1B (SAR1b) is involved in transport from the endoplasmic reticulum to the Golgi apparatus and also in the selection of the protein cargo and the assembly of the COPII coat complex. The SAR1B protein is activated by the guanine nucleotide exchange factor PREB. SAR1B gene defects are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD).
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Overview