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Recombinant Human GRK7 (N-GST tag)

Recombinant Human GRK7 (N-GST tag)

Catalog Number:

E001278344APP

Mfr. No.:

Z500159

Price:

$672

Size:

10 µg

Quantity:

Add to Cart:

- Overview
  - GRK7 is a member of the G protein-coupled receptor kinase subfamily and is a Ser/Thr protein kinase. GRK7 is specifically expressed in the retina and has been shown to phosphorylate cone opsins and initiate their deactivation. GRK7 catalyzes rhodopsin phosphorylation in a light-dependent manner. GRK7 co-localizes with GRK1 in human cone outer segments. PKA phosphorylates GRK7 at Ser(23) and Ser(36) in vitro and phosphorylation of GRK7 by PKA reduces the ability of GRK7 to phosphorylate rhodopsin in vitro. Since exposure to light causes a decrease in cAMP levels in rod cells, it is proposed that phosphorylation of GRK7 by PKA occurs in the dark.
    
    Please contact us at for specific academic pricing.
- Properties
  - Name
    
    GPRK7
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
    
    Storage
    
    Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    
    Molecular Weight
    
    89.0 kDa
    
    Class
    
    Active Kinases
    
    * For research use only. Not for diagnostic or therapeutic use.

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