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Overview
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Glial Cell Line-Derived Neurotrophic Factor Family Receptor -Alpha-1 (GDNFR-Alpha1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor -Alpha subtype which consists of at least four members. GFR-Alpha1and GFR-Alpha2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFR-Alphas released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFR-Alpha1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFR-Alpha1 shares 93% amino acid identity with mouse GFR-Alpha1. The expression of the various GFR-Alphas are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFR-Alphas in mediating the activities of the GDNF family of neurotrophic factors.
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