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Recombinant Human EIF2AK2 (N-GST tag)

Recombinant Human EIF2AK2 (N-GST tag)

Catalog Number:
E001278305APP
Mfr. No.:
Z500116
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • EIF2AK2 (also known as double-stranded RNA-activated protein kinase) is a protein kinase that has been shown to be involved in HIV/gp120-associated neurodegeneration. EIF2AK2 acts as a critical mediator of gp120 neurotoxicity and is a substrate for a family of protein kinases that respond to various forms of environmental stress. Activation of EIF2AK2 leads to its autophosphorylation and then phosphorylation of its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2. EIF2AK2 plays a critical role in mRNA translation, cell proliferation and apoptosis. A novel cross-talk between the EIF2AKs and p53 has been shown that has implications in cell proliferation and tumorigenesis.

          Please contact us at for specific academic pricing.

      • Properties
        • Name
          PKR, PRKR, EIF2AK1
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          64.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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