Recombinant Human DMPK (N-GST tag)

Recombinant Human DMPK (N-GST tag)

Catalog Number:
E001278295APP
Mfr. No.:
Z500106
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
      • Overview
        • DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein. Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3' untranslated region of DMPK.

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      • Properties
        • Name
          DM, DM1, DMK, MDPK, DM1PK, MT-PK
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          105.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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