Name: Recombinant Human Cytokeratin 17
Price: Inquiry

- Overview
  - KRT17 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 455 amino acids (1-432 a.a) andhaving a molecular mass of 50.5kDa. KRT17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Cytokeratin17 also known as KRT17 is a type I cytokeratin. KRT17 is found in nail beds,hair follicles, sebaceous glands, and other epidermal appendages. Mutations inKRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystomamultiplex. KRT17 takes part in the formation and maintenance of a variety ofskin appendages, particularly in determining shape and orientation of hair. KRT17also modulates the function of TNF-alpha in the precise context of haircycling. Moreover, KRT17 regulates protein synthesis and epithelial cell growthall through binding to the adapter protein SFN and by stimulating Akt/mTORpathway.
    
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- Properties
  - Protein Name
    
    Keratin 17, PCHC1, 39.1, CK-17, K17, PC2, PC, cytokeratin-17, Keratin 17 Epitope S1, Keratin 17 Epitope S2, Keratin 17 Epitope S4, Keratin, Type I Cytoskeletal 1, keratin-17, Cytokeratin-17, Keratin-17.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greaterthan 90% as determined by SDS-PAGE.
    
    Formulation
    
    KRT17 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Cytokeratin 17

Recombinant Human Cytokeratin 17

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