Recombinant Human CHK2 (N-GST tag)

Recombinant Human CHK2 (N-GST tag)

Catalog Number:
E001278278APP
Mfr. No.:
Z500082
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
      • Overview
        • CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner. Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization.

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      • Properties
        • Name
          RP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          88.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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