Name: Recombinant Human Cellular Tumor Antigen p53 (N-His)
Price: Inquiry

- Overview
  - p53 is a DNA-binding protein that belongs to the p53 family. p53 is expressed ubiquitously and its isoforms are expressed widely in normal tissues but in a tissue-dependent manner. It is well known for its key role as a tumor suppressor protein. p53 induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is also involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Whilst the activation of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression. Mutants of p53, which frequently occur in different human cancers, fail to bind the consensus DNA binding site, and thus cause the loss of tumor suppressor activity. Defects in TP53 are a cause of esophageal cancer, Li-Fraumeni syndrome, lung cancer and adrenocortical carcinoma.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    Antigen NY-CO-13; BCC7; FLJ92943; LFS1; LFS1TRP53; p53 tumor suppressor; p53; P53cellular tumor antigen p53; Phosphoprotein p53; TP53; transformation-related protein 53; TRP53; tumor protein p53; Tumor suppressor p53
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Supplied as a 0.2 um filtered solution of 2umM Tris, 30umM NaCl , 5% glycerol , umM DTT, 0.0umM ZnCl2, pH8.0
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Cellular Tumor Antigen p53 (N-His)

Recombinant Human Cellular Tumor Antigen p53 (N-His)

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