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Recombinant Human CD3E (C-His)

Recombinant Human CD3E (C-His)

Catalog Number:
P001415362ABE
Mfr. No.:
Abe32-9160
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      • Overview

        • CD3 epsilon (T-Cell Surface Glycoprotein CD3 Epsilon) is a type I transmembrane protein that belongs to the immunoglobulin superfamily. There are four CD3 proteins: CD3 delta, CD3 epsilon, CD3 gamma, and CD3 zeta. All CD3 proteins contain ITAM (Immunoreceptor Tyrosine-based Activation Motifs) in the cytoplasmic tail, which becomes phosphorylated by Src family protein tyrosine kinases LCK and FYN upon TCR engagement. CD3 proteins form heterodimers of CD3 delta/CD3 epsilon and CD3 gamma /CD3 epsilon, which bind to TCR and form trimeric TCR alpha /CD3 epsilon /CD3 gamma and TCR beta /CD3 gamma /CD3 epsilon. The resulting heterohexamer further associates with CD3 zeta homodimer and forms TCR/CD3 signaling complex. This complex is involved in coupling antigen recognition to several intracellular signal-transduction pathways. CD3 epsilon plays a critical role in adaptive immune response. Defects in CD3 epsilon lead to SCID (severe combined immunodeficiency).

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      • Properties
        • Protein Name
          T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e; CD3E; T3E
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 um filtered solution of PBS, pH7.4

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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