Recombinant human CD27 protein with C-terminal human Fc tag

Recombinant human CD27 protein with C-terminal human Fc tag

Catalog Number:
P001417495ABE
Mfr. No.:
Abe32-17087
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      • Overview
        • The protein has a predicted molecular mass of 45.3 kDa after removal of the signal peptide. The apparent molecular mass of CD27-hFC is approximately 55-70 kDa due to glycosylation. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

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      • Properties
        • Protein Name
          CD27, TNFRSF7, S152, T14, Tp55
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Purification
          The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
          Formulation
          Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
          Storage
          Store at -80°C for 12 months (Avoid repeated freezing and thawing)

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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