Name: Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 (C-6His)
Price: Inquiry

- Overview
  - MW : 8.5kD. Recombinant Human C-X-C Motif Chemokine 4 is produced by our Mammalian expression system and the target gene encoding Glu32-Ser101 is expressed with a 6His tag at the C-terminus. Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    Human cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
    
    Storage
    
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    P02776
    
    Gene ID
    
    5196
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 (C-6His)

Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 (C-6His)

More Information

We Also Recommend

Recombinant Human cAMP-Dependent Protein Kinase 1a/PRKAR1A (C-6His)

Recombinant Human GDNF Receptor a-2/GFRA2 (C-Fc-6His)

Recombinant Human Serpin B9/SERPINB9 (C-6His)