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Recombinant Human beta-Galactoside a-2,6-Sialyltransferase 1/ST6GAL1 (C-6His)

Recombinant Human beta-Galactoside a-2,6-Sialyltransferase 1/ST6GAL1 (C-6His)

Catalog Number:
P001411690ABE
Mfr. No.:
Abe32-7453
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      • Overview

        • MW : 44.6kD. Recombinant Human ST6GAL1 is produced by our Mammalian expression system and the target gene encoding Lys27-Cys406 is expressed with a 6His tag at the C-terminus. The ST6GAL1 gene encodes beta-Galactosamide a-2,6-Sialyltransferase 1. It is a type II membrane protein and is localized to the trans-Golgi network. It catalyzes 2,6-sialylation of Gal beta1,4-GlcNAc structures on N-glycans. ST6GAL1 is highly expressed in the liver and other tissues. ST6GAL1 deficiency causes abnormalities in B-cell immunoreactivity. The expression and activity of ST6GAL1 are associated with tumor metastasis in breast and colon cancers. The majority of ST6GAL1 in the liver is cleaved and secreted into the serum and may be used as a biomarker for hepatitis diseases.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
          Storage
          Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          P15907
          Gene ID
          6480

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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