Recombinant Human BAFF-R protein with C-terminal human Fc

- Overview
  - The protein has a predicted molecular mass of 32.7 kDa after removal of the signal peptide. The apparent molecular mass of BAFF-R-hFc is approximately 35-55 kDa due to glycosylation. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
    
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- Properties
  - Protein Name
    
    BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin
    
    Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
    
    Formulation
    
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    
    Storage
    
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human BAFF-R Protein, hFc Tag on SDS-PAGE under reducing condition.

Recombinant Human BAFF-R protein with C-terminal human Fc

Recombinant Human BAFF-R protein with C-terminal human Fc

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