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Recombinant Human Autophagy Related 4 Homolog C/ATG4C (C-6His)

Recombinant Human Autophagy Related 4 Homolog C/ATG4C (C-6His)

Catalog Number:
P001411045ABE
Mfr. No.:
Abe32-8105
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      • Overview

        • MW : 53.56kD. Recombinant Human Autophagy protein 4C is produced by our E.coli expression system and the target gene encoding Met1-Leu458 is expressed with a 6His tag at the C-terminus. Cysteine Protease ATG4C (ATG4C) belongs to the peptidase C54 family. It is required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form which is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ATG4C is a cytoplasmic protein and high expressed in skeletal muscle, liver, testis and heart. ATG4C can be inhibited by N-ethylmaleimide.

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      • Properties
        • Source
          E. coli
          Type
          Recombinant Proteins
          Formulation
          Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 100mM NaCl, 10% Glycerol, pH 8.0.
          Storage
          Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
          Endotoxin
          Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

          More Information

          UniProt
          Q96DT6
          Gene ID
          84938

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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