Name: Recombinant human 4-1BB Ligand Protein with N-mouse Fc and C-6×His tag
Price: Inquiry

- Overview
  - The protein has a predicted molecular mass of 49.8 kDa after removal of the signal peptide. The apparent molecular mass of mFc-4-1BB Ligand-His is approximately 53-70 kDa due to glycosylation. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    4-1BB Ligand, TNFSF9, CD137L
    
    Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
    
    Formulation
    
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    
    Storage
    
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human 4-1BB Ligand Protein, mFc-His Tag on SDS-PAGE under reducing condition.

Recombinant human 4-1BB Ligand Protein with N-mouse Fc and C-6×His tag

Recombinant human 4-1BB Ligand Protein with N-mouse Fc and C-6×His tag

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