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Overview
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The E.coli derived recombinant 28 kDa protein is genetically engineered peptide which is derived from Dengue Type-3 Envelope. This region also contains a common antigen for Dengue type 1, 2 and 4. The sequence is from Dengue virus type 3 strain C0360/94, genebank access code is AY923865. Caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholino antisense oligos have shown specific activity against Dengue virus.
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