Name: Ranolazine
Price: 196.00 USD

- Overview
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    Background
    
    Ranolazine is an anti-ischemic which inhibits late sodium current that results in a reduction of Na+ dependent Ca2+ overload. Studies indicate that ATP production is shifted towards glucose oxidation by Ranolazine. This is due to the fact that more oxygen is required to phosphorylate the same amount of ATP during fatty acid oxidation than carbohydrate oxidation. These studies indicate that Ranolazine also inhibits oxygen consumption and ketogenesis by fatty acids in liver cells.
- Properties
  - Categories
    
    Anti-ischemic
    
    Alternative Name
    
    N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
    
    CAS Number
    
    95635-55-5
    
    Molecular Formula
    
    C24H33N3O4
    
    Molecular Weight
    
    427.54
    
    Appearance
    
    A solid
    
    Purity
    
    99.43%
    
    Solubility
    
    insoluble in H2O; ≥13.18 mg/mL in EtOH with ultrasonic; ≥17.4 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
    
    * For Research Use Only
- Reference
  - 1. Blanchette AD, Grimm FA, et al. "Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships." Clin Pharmacol Ther. 2018 Oct 22. PMID:30346629