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Overview
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Background
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated witHuman, Mouseultiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12.
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