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Overview
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Background
SLTM (SAFB-like, transcription modulator), also known as MET (modulator of estrogen-induced transcription), is a 1,034 amino acid protein that localizes to punctate structures within the nucleus and contains one SAP domain and one RNA recognition motif. When expressed at high levels, SLTM functions to inhibit transcription and may, ultimately, lead to apoptosis. Multiple isoforms of SLTM exist due to alternative splicing events. The gene encoding SLTM maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
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