Rabbit anti-NOTCH1 Polyclonal Antibody

Rabbit anti-NOTCH1 Polyclonal Antibody

Catalog Number:
A001075352RED
Mfr. No.:
RD76518A
Price:
$253
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      • Overview
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          Background

          This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; rat
          Immunogen
          Synthetic peptide of human NOTCH1
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% sodium azide, 50% glycerol, PH7.3
          Storage
          Store at -20°C. Avoid repeated freeze / thaw cycles.
          Concentration
          0.4mg/mL
          Antigen
          hN1; Neurogenic locus Notch homolog protein 1; NICD; NOTC1; Notch 1; Notch 1 intracellular domain; Notch homolog 1 translocation associated (Drosophila); notch1; TAN1; Translocation-associated notch protein TAN-1 (UniProt:P46531)

          * For research use only.

      • Applications
        • Application
          WB; IHC; ELISA

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