Name: Rabbit anti-KIR3DS1 Polyclonal Antibody
Price: 416.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Properties
  - Host
    
    rabbit
    
    Antibody Type
    
    polyclonal
    
    Isotype
    
    IgG
    
    Reactivity
    
    human; mouse; rat
    
    Immunogen
    
    Recombinant protein of human KIR3DS1
    
    Purification
    
    Affinity purification
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    
    Storage
    
    Store at -20°C. Avoid repeated freeze / thaw cycles.
    
    Concentration
    
    1mg/ml
    
    Antigen
    
    Killer Cell Immunoglobulin Like Receptor Three Ig Domains And Short Cytoplasmic Tail 1; Killer Cell Immunoglobulin-Like Receptor Three Domains; Short Cytoplasmic Tail 1; Natural Killer-Associated Transcript 10; NKAT-10; NKAT10; Killer Cell Immunoglobulin-Like Receptor KIR3DS1; Killer Cell Immunoglobulin-Like Receptor 3DS1; MHC Class I NK Cell Receptor; KIR-123FM; CD158E2; KIR-G1 (Gene ID:3813; UniProt:Q14943)
    
    * For research use only.
- Applications
  - Application
    
    WB