Name: Rabbit anti-Glucocorticoid Receptor Polyclonal Antibody (1mg/ml) for WB, IHC
Price: 347.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
- Properties
  - Host
    
    rabbit
    
    Antibody Type
    
    polyclonal
    
    Isotype
    
    IgG
    
    Reactivity
    
    human; mouse
    
    Immunogen
    
    Recombinant protein of human NR3C1
    
    Purification
    
    Affinity purification
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    
    Storage
    
    Store at -20°C. Avoid repeated freeze / thaw cycles.
    
    Concentration
    
    1mg/ml
    
    Antigen
    
    GCCR; GCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; GRL; Grl1; nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3; group C; member 1 (glucocorticoid receptor) (Gene ID:2908; UniProt:P04150)
    
    * For research use only.
- Applications
  - Application
    
    WB; IHC