Name: Rabbit anti-DUSP8 Polyclonal Antibody
Price: 253.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
- Properties
  - Host
    
    rabbit
    
    Antibody Type
    
    polyclonal
    
    Isotype
    
    IgG
    
    Reactivity
    
    human; mouse
    
    Immunogen
    
    Synthetic peptide of human DUSP8
    
    Purification
    
    Affinity purification
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    PBS with 0.05% sodium azide, 50% glycerol, PH7.3
    
    Storage
    
    Store at -20°C. Avoid repeated freeze / thaw cycles.
    
    Concentration
    
    0.4mg/mL
    
    Antigen
    
    C11orf81; Chromosome 11 open reading frame 81; Deubiquitinating enzyme 8; Dual Specificity Phosphatase 8; Dual specificity phosphatase M3/6; Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH 5; Dual specificity protein phosphatase hVH-5; DUS8; DUS8; DUSP8; EC 3.1.3.16; EC 3.1.3.48; FLJ42476; FLJ42958; H1 phosphatase vaccinia virus homolog; H1 phosphatase; vaccinia virus; homolog of; HB5; hUBPy; HVH5; HVH8; M3/6; mouse; homolog of; Neuronal tyrosine threonine phosphatase 1; Serine/threonine specific protein phosphatase; Ubiquitin carboxyl terminal hydrolase 8; Ubiquitin specific processing protease 8; Ubiquitin thiolesterase 8; VH5 (UniProt:Q13202)
    
    * For research use only.
- Applications
  - Application
    
    IHC; ELISA