Name: (R)-(+)-Etomoxir sodium salt
Price: 234.00 USD

- Overview
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    Background
    
    (R)-(+)-Etomoxir sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1(CPT-1)[1].
    Etomoxir (100 μM) has no effect on T cells cultured in high glucose. In contrast, there is a significant increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions[2].
    C57BL/6 mice treated with Etomoxir (15 mg/kg, i.p) reduce the infiltration of immune cells in the central nervous system. Only a small number of macrophages, activated microglia or T cells are present, while reducing the inflammatory response and Demyelinating reaction[2].
    
    [1]. Rupp H, Zarain-Herzberg A, Maisch B. The Use of Partial Fatty Acid Oxidation Inhibitors for Metabolic Therapy of Angina Pectoris and Heart Failure. Herz, 2002, 27(7): 621-636.
    [2]. Shriver L P, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1.
- Properties
  - Alternative Name
    
    sodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
    
    CAS Number
    
    828934-41-4
    
    Molecular Formula
    
    C15H18ClNaO4
    
    Molecular Weight
    
    320.74
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥12 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

(R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt

Background

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