Quin 2

- Overview
  - Quin 2 forms a stable fluorescent complex with calcium (logKCaY=7.1), but not with magnesium (logMgY=2.7). The complex has a high quantum yield (0.14) at emission wavelength 525 nm, excitation wavelength 339 nm, and emission wavelength 492 nm. Quin 2-AM is an acetoxymethyl ester derivative of Quin 2 that is readily permeable through cell membranes. Within the cell, the ester is hydrolyzed to Quin 2.
    
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- Properties
  - Categories
    
    Intracellular Fluorescent Probes
    
    CAS Number
    
    73630-23-6
    
    Molecular Formula
    
    C26H23K4N3O10
    
    Molecular Weight
    
    693.87
    
    Appearance
    
    pale yellow powder
    
    Purity
    
    ≥95.0 %(HPLC)
    
    Storage
    
    ambient temperature, protect from light and moisture
    
    Shipping
    
    ambient temperature
    
    * For research use only
- Reference
  - 1) R. Y. Tsien, New Calcium Indicators and Buffers with High Selectivity against Magnesium and Protons: Design, Synthesis, and Properties of Prototype Structures. Biochemistry. 1980;19:2396-2404.
    
    2) R. Y. Tsien, et al., Calcium Homeostasis in Intact Lymphocytes: Cytoplasmic Free Calcium Monitored with a New, Intracellularly Trapped Fluorescent Indicator. J Cell Biol. 1982;94:325-334.
    
    3) M. B. Feinstein, et al., The Cytoplasmic Concentration of Free Calcium Inplatelets Is Controlled by Stimulators of Cyclic AMP Production (PGD2, PGE1, FORSKOLIN). Biochem Biophys Res Commun. 1983;113:598-604.
    
    4) N. Miyoshi, et al., A New Method of Determining Intracellular Free Ca2+ Concentration Using Quin2-fluorescence. Photochem Photobiol. 1991;53:415-418.

MSDS

Quin 2

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