Name: PTEN, Monoclonal Antibody
Price: 200.00 USD

Overview
- Sensitivity: Endogenous
  Target name: PTEN, monoclonal antibody
  Area: Cell biology/Cell Cycle/Cancer
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Properties
- Host
  
  Mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  mAb
  
  Storage
  
  Long time storage is recommended at -20°C
  Phosphate-buffered solution, pH 7.2, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
  
  Molecular Weight
  
  55
  
  * For research use only.