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Overview
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Serine434/Serine441 (S437/S441) is a major phosphorylation site of the CRF1 receptor. The pS434/pS437-CRF1 antibody detects phosphorylation in response to high-efficacy agonists. S434/S437 phosphorylation is a key regulator of CRF1 desensitization, β-arrestin recruitment and internalization. S434/S437 also undergoes constitutive phosphorylation.
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