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Overview
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Serine385/Serine386 is a major phosphorylation site of the M3 Muscarinic Acetylcholine Receptor. The pS385/pS386-M3 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S385/S386 phosphorylation is a key regulator of M3 desensitization, β-arrestin recruitment and internalization.
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